Clinical Trial Evidence of Biotin's Benefit in Type-2 Diabetes

Clinical trial results show biotin can help reduce HbA1c and fasting blood glucose levels.

A recent 90-day, large, double-blind clinical trial involving 447 type-2 diabetic participants demonstrated that a combination of chromium picolinate and biotin significantly reduced both glycated hemoglobin Hba(1c) and fasting glucose levels, with no adverse side effects. This larger trial corroborated results of a smaller randomized, controlled study involving similar patients in 2006. All study participants had poorly controlled blood sugar levels, as defined by Hba(1c) levels of 7.0% or above (6.0% is considered to be normal).40-42

HbA(1c) test results reflect blood glucose levels over a period of 2-3 months, and higher numbers indicate poor glucose control for weeks. This increases the risk of diabetic complications, including heart and kidney disease, nerve damage, and vision loss. All the study subjects also had the additional health risks associated with being overweight and/or obese.42


The 447 participants were randomly assigned to a treatment or a look-alike placebo group. The treatment group received 600 µg chromium picolinate with 2 mg biotin a day. Both groups continued with oral anti-diabetic medications. All of the treatment group subjects who took chromium picolinate, biotin, and anti-diabetic drugs reduced fasting blood sugar levels, while the placebo/anti-diabetic drug control subjects experienced an increase in fasting glucose. The treatment group also had significantly better HbA(1c) reductions than the control group - especially those whose baseline HbA(1c) had been 10% or more. Biotin and chromium picolinate exerted greater effects on fasting blood glucose in this sub-group of study participants.40

Healthier cholesterol ratios may be an added benefit of chromium picolinate and biotin supplementation for diabetics. Results of this large clinical trial showed that the biotin/chromium picolinate treated test group had significant improvements in cholesterol levels , which may also be an indicator of insulin resistance status. Lower cholesterol levels reduce the risk of heart disease.40

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Iron-containing protein in red blood cells (which transport oxygen), bound to glucose.6, 40
Also known as A1C, A1c, or Hb 1c..40
Micrograms; 1 microgram equals 1/1000 of a milligram..6
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