Symptoms of Biotin Deficiency

Biotin deficiency can cause symptoms such as muscle weakness, anemia, hair loss, and fatigue.

Symptoms of biotin deficiency vary widely because biotin is involved in so many biochemical processes in the body.4 Clinical signs may include:

  • Anemia.3
  • Ataxia.7
  • Depression.1, 5
  • Developmental delays.18
  • Elevated cholesterol levels.3
  • Fatigue.1, 5
  • Hair loss and thinning hair.1, 7
  • Hallucinations.1, 5
  • Banner
  • Heart function impairment.3, 8
  • Increased number of bacterial and fungal infections due to impaired immunity.3, 5
  • Insomnia.3
  • Leiner's disease.4
  • Loss of appetite.3
  • Loss of hair color.1
  • Loss of hearing.10
  • Mental retardation.7
  • Muscle pain.3
  • Muscle weakness.7
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  • Numbness, burning, and tingling in arms, legs, hands, and feet.1, 3, 5
  • Pallor.3
  • Red and scaly skin rash (around eyes, mouth, nose, and genitals); usually tests positive for the yeast infection Candida.18
  • Seizures and other neurological problems.10
  • Sore tongue.3
  • Unusual urinary odor.4
  • Vision problems.10
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Loss of muscle coordination and balance.6
Typically with inherited metabolic disorders.7
Acute generalized seborrhoeic dermatitis in infants.50
Unusually pale skin.6
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