Higher amounts of biotin have been prescribed for conditions such as diabetes and biotinidase deficiency. Some experts suggest taking manganese with biotin for best results when taken to help clear skin conditions, since biotin needs certain enzymes to function in the skin that manganese helps to activate.1, 54
There has been no upper limit set for safe/tolerable biotin dosage. However, one study based on food frequency questionnaires suggests that doses of biotin higher than 600 Î¼g/day may increase risk of DNA damage.63
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There are no recommended dietary allowances (RDAs) for biotin..1
Microgram, 1/1000th of a milligram.6