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Symptoms of Biotin Deficiency

Symptoms of biotin deficiency vary widely because biotin is involved in so many biochemical processes in the body.4 Clinical signs may include:

  • Anemia.3
  • Ataxia.6
  • Depression.1
  • Developmental delays.17
  • Elevated cholesterol levels.3
  • Fatigue.1,5
  • Hair loss6 and thinning hair.1
  • Hallucinations.1,5
  • Heart function impairment.3,7
  • Increased number of bacterial and fungal infections due to impaired immunity.3,5
  • Insomnia.3
  • Leiner’s disease.4
  • Loss of appetite.3
  • Loss of hair color.1
  • Loss of hearing.9
  • Mental retardation.6
  • Muscle pain.3
  • Muscle weakness.6
  • Can you reverse gray hair? Reviewers of all-natural Go Away Gray, which contains biotin and other nutrients, suggest it might help. Experts say gray and thinning hair could be a symptom of biotin deficiency. (1)
  • Numbness, burning, and tingling in arms, legs, hands, and feet.1,3,5
  • Pallor.3
  • Red and scaly skin rash (around eyes, mouth, nose, and genitals); usually tests positive for the yeast infection Candida.
  • Seizures and other neurological problems.9
  • Sore tongue.3
  • Unusual urinary odor.4
  • Vision problems.9
Disclaimer: This website is not intended to replace professional consultation, diagnosis, or treatment by a licensed physician. If you require any medical related advice, contact your physician promptly. Information at is exclusively of a general reference nature. Do not disregard medical advice or delay treatment as a result of accessing information at this site.
Loss of muscle coordination and balance.
Typically with inherited metabolic disorders.
Acute generalized seborrhoeic dermatitis in infants.
Unusually pale skin.
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